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The 12-month trial design enables us to assess senolytic-associated changes before and after treatment during the 3-month active treatment phase, track the reappearance of senescent cells after their removal during the 9-month post-treatment period, and evaluate disease trajectory differences over a one-year period (Figure 3)
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Resmetirom: acts on the MASH and fibrosis regression by intrahepatic path Resmetirom is an orally administered, liver-targeted thyroid hormone receptor- (THR) selective agonist
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