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NNMT depletes the NAD+ precursor pool by methylating nicotinamide the same nicotinamide that the salvage pathway would otherwise convert back into NAD+ via the enzyme NAMPT

The two routes of administration are fundamentally different worlds, governed by different biological rules

This change in secretion was interpreted as a cellular response to mitigate the toxic buildup of Gb-3, involving mechanisms like enhanced p53 expression (121, 131)

You also get far lower carb, fat, sugar and calories than in the heavily advertised flagship nutrition drinks you see on TV