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Using random forest regression as the predictive model, we identified pathways commonly associated with NRF2, such as reactive oxygen species (ROS) and xenobiotic metabolism, in addition to reduced glutathione and NADP levels, as top features associated with NRF2 dependency (Fig

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Additionally, more large-scale, long-term human studies are needed to fully establish the comparative effectiveness of S-acetyl L-glutathione versus regular glutathione across various health outcomes