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Clinical trials reveal up to 20.9% body weight loss, making it the most effective among weight loss medications currently on the market

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It says the majority of that early drop represents water and glycogen rather than adipose tissue, and lists four contributors: reduced caloric intake from appetite suppression, decreased water retention as insulin levels normalize, slowed gastric emptying, and minor glycogen depletion

Reversible DPP-4 blockade therefore not only preserves incretins but also curtails leukocyte chemotaxis and endothelial dysfunction [22]