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It is widely believed that methylphenidate produces its therapeutic effects in ADHD by increasing dopamine level, which is similar to the actions of TAT-DAT NT as supported the microdialysis data (Fig
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On the other hand, oxidative stress leads to an increase in the release of cytochrome C from the mitochondria which activates the apoptotic mechanism in the cells by activating caspases (caspase-3/7, 8 and 9) and pushing the cells to the programmed cell death
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