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Heider J, Vogel S, Volkmer H, Breitmeyer R

In a 2-year carcinogenicity study in Sprague Dawley rats, subcutaneous doses of 0.0025, 0.01, 0.025 and 0.1 mg/kg/day were administered (below quantification, 0.8-, 1.8- and 11-fold the exposure at the MRHD)

Activity sessions with a maximum heart rate below 120bpm or a duration outside 10 minutes to 3 hour range were excluded to avoid automatic or noisy records

Lifileucel is given as a single injection

This trend represents a serious public health concern, as obesity is linked to increased mortality and is a major risk factor for health conditions including cardiovascular disease and type II diabetes