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AD is divided into early-onset and late-onset (EOAD/LOAD) variants, with the age of differentiation being 65 years [87]

Anales de Dermatologa , 28 (4), 438

Anastrozole is a commonly prescribed medication used to manage estrogen levels in individuals undergoing hormone therapy, including those on testosterone replacement therapy

Numerous studies have evaluated lactulose in the treatment of minimal HE, overt HE, and as a secondary prophylactic measure in patients with cirrhosis, confirming its efficacy and safety.3033 Clinical trials have shown that lactitol is better-tolerated and is just as efficacious as lactulose for the treatment of HE.34,35 No significant difference has been found with respect to improving HE grade in the comparison of nonabsorbable antibiotics (rifaximin) versus nonabsorbable disaccharides (lactitol and/or lactulose).23,25,27 Probiotics are mixtures of beneficial bacteria that are believed to aid in the treatment of HE by modulating the microbiome

Astrocytes sense extracellular changes through receptors such as pattern recognition receptors and cytokine receptors, detecting pathogens, A aggregates or inflammatory mediators 4,41