Human trial data are inconsistent but suggest variability between drugs and formulations: exenatide (Bydureon) reached 1%3% of peripheral levels in CSF (156), while another formulation of once-weekly exentide (Bcise) only achieved approximately 1% of peripheral levels detectable in CSF (61)
So, we decided the study design be based on the pre-post intervention model
However, direct ordering does not replace a prescribing clinician
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