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conducted a cohort study including 11,169 participants, with a median follow-up period of 24.1 years [115]

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54 This ability is simply due to the serum abundance of IGFBP-3, 55 thereof the ternary complex of IGF-1, IGFBP-3, and an acid-labile subunit is principally seen to modulate antiproliferative activity in breast cancer