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The treatment was well tolerated with minimal side effects, but it did not significantly reduce the incidence of SR GVHD compared to the control group

For example, berberine was found to inhibit cardiac fibroblast proliferation and myofibroblast differentiation by modulating AMPK/PGC-1 signaling, helping to alleviate cardiac fibrosis in models of ischemic or diabetic cardiomyopathy ( Corydalis species) can increase the interaction between PPAR- and NF-B p65, thereby inhibiting NF-B pro-inflammatory signaling and ameliorating cardiac inflammation (Wang M

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Subsequent interaction of H 2 O 2 and O 2 in the HaberWeiss reaction, or Fe 2+ (or Cu 2+ )driven cleavage of H 2 O 2 in a Fenton reaction, can generate the highly reactive hydroxyl radical (OH) [26], which is the most harmful ROS and can give rise to the formation of lipid (L) and lipid peroxyl (LOO) radicals [25]

10.1038/ngeo685 Nat