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intriguingly, low-grade hyperketonemia (not leading to ketoacidosis, a rare, life-threatening side effect) may contribute to cardio-renal benefits and other effects, such as anti-inflammatory and antioxidant effects [188]

Con L-carnitina: Favorece el metabolismo y transformacin de grasa en energa

There is also a need to design additional experiments in the context of diabetes aimed at comparing the cardiovascular effects of incretin-based therapies to other glucose-lowering therapies and analyzing in depth the impact such therapies may have on different comorbid conditions associated with this disease, including obesity, hyperlipidemia, high blood pressure, renal failure, and so on.72 In this same conceptual framework, experiments to compare the cardioprotective efficacy of different therapies based on GLP-1 should be considered, particularly because GLP-1R and DPP-4 inhibitors have different actions depending on whether they are assessed in the metabolic or cardiovascular setting.14,72,73 In this regard, mention should be made of the multiple experimental observations attributing a cardioprotective activity to the GLP-1 (936) peptide, whose blood levels may be influenced by the type of incretin-based therapy administered

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Protective effects of carvedilol against anthracycline-induced cardiomyopathy