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For over 20 years, Professor Mikelsaar and her colleagues worked with the Russian space program studying the intestinal probiotics of Russian cosmonauts in zero gravity during extended space flights

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doi: 10.1016/j.glmedi.2024.100081 [DOI] [Google Scholar] 5.Uddin TM, Chakraborty AJ, Khusro A, et al

More commonly used than droxidopa: Midodrine was approved in the 1990s (droxidopa was approved in 2014) Most clinicians have longer experience with midodrine Midodrine is available as a generic & is less expensive Droxidopa is typically reserved for use as an add-on when midodrine is ineffective, or midodrine is not tolerated due to side effects Contraindications: hypertension heart failure acute kidney failure urinary retention thyrotoxicosis pheochromocytoma Side Effects: Supine hypertension WARNING : may cause marked hypertension when the patient is supine (laying down)

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