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Sermorelin and Tesamorelin have extremely short half-lives of roughly 1126 minutes because they are minimally modified growth hormone-releasing hormone analogs that are rapidly cleaved by dipeptidyl peptidase-4 and other serum proteases

BPC-157s safety profile appears favorable based on animal trials

Several mechanisms and risk factors can lead to oxidative overload (Tian et al., 2022), including the upregulation of fatty acid oxidation that increases NADH and FADH2 load

Clinical translation would require trials in cardiac patient populations with appropriate safety monitoring given theoretical concerns about blood pressure effects and vascular remodeling