Questions to ask your doctor (if you want to be practical about it) If this headline has you spiraling a bit, bring a short list to your next appointment
Key Points Oxidative stressgenerated through multiple mechanisms in a cell-type-specific manneris a substantial contributor to disease pathogenesis, organ damage and comorbidities in patients with systemic lupus erythematosus (SLE) Pathways of oxidative pathogenesis, such as oxidative modification of self antigens and T-cell dysfunction, have been identified Organ systems in which the clinical importance of oxidative damage in SLE has been recognized include the cardiovascular and renal systems and the skin Biomarkers of oxidative stress correlate directly with disease activity in SLE Depletion of glutathione (reflecting oxidative stress) might have a pathogenic role
Shou WZ, Magis L, Li AC, Naidong W, and Bryant MS (2005) A novel approach to perform metabolite screening during the quantitative LC-MS/MS analyses of in vitro metabolic stability samples using a hybrid triple-quadrupole linear ion trap mass spectrometer, J Mass Spectrometry 40 : 1347- 1356 Wayman GA, Davare M, Ando H, Fortin D, Varlamova O, Cheng HY, Marks D, Obrietan K, Soderling TR, Goodman RH and Impey S (2008) An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP
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Over time, the pancreas may struggle to keep up with the heightened demand for insulin, causing further elevation of blood sugar levels
