When you take an oral tablet, the medication reaches your digestive system and enters your bloodstream, where it activates GLP-1 receptors in the brain and gut
BMC Endocr Disord (2020) 20(1):177
While the percentage of TEAEs related to study drug were numerically higher for the buntanetap doses, they were not statistically different than placebo, nor was there a dose-dependent relationship between the number of related TEAEs (10.5%, 9.4%, and 6.9% in 7.5 mg, 15 mg, and 30 mg, respectively)
However, the FDA has received voluntary reports from patients describing emotional numbness, reduced motivation, and depressive symptoms after starting GLP-1 therapy, though causality remains unclear
The IC 50 of SU11274 was between 1 and 2.5 mol/L and apoptosis was observed in five melanoma cell lines that expressed c-Met [65]