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Work from David Savages group showed that PLIN1 mutations from patients with lipodystrophies, which lack the C-terminus, fail to stabilize ABHD5 on LDs, resulting in greater basal lipolysis (137) and likely explains why these patients are unable to sequester FAs into TAGs

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The syringes are specially designed for use with the Self-Injector and the thin needle gauge provides a less painful experience

PNPLA1 is a transacylase essential for the generation of the skin barrier lipid - O -acylceramide

Subsequent studies have expanded its research applications to include investigations into its anti-inflammatory, antioxidant, and gene-modulatory effects