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2,3 In 2021, the International Scientific Association of Probiotics and Prebiotics (ISAPP) proposed the following definition for a postbiotic a preparation of inanimate microorganisms and/or their components that confers a health benefit on the host. Essentially, postbiotics may contain the inactivated probiotics themselves and the compounds secreted by the probiotics while alive

As discussed by Benington, any proposed function of sleep should describe how the progress of that function determines sleep need (Tononi and Cirelli, 2003, 2006), heightened SWA is not caused by stronger synapses in wakefulness, nor does it result only in synaptic weakening during sleep

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