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TB-500: 5 mg per week split into 2 to 3 doses for 6 weeks, then 2 to 3 mg per week for 4 weeks maintenance

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Deep IM injection in gluteal/deltoid muscle Typical regimen: 2ml every other day or 3x/week Acute cases: Daily for 5-7 days then reduce frequency Maintenance: Weekly/monthly depending on condition Rotate injection sites to prevent tissue irritation The synergy enhances: nerve regeneration (B12), pain modulation (B6), and carbohydrate metabolism (B1)

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All experiments were approved by the Ethics Committee of the Plastic Surgery Hospital (Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China