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The safety implications of receptor desensitization include possible changes in the dose-response relationship over time and the possibility that higher doses may be needed to achieve similar effects in long-term protocols

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[DOI] [PubMed] [Google Scholar] Galloway DC, McLellan LI

Risk of cardiovascular disease and all-cause mortality among diabetic patients prescribed rosiglitazone or pioglitazone: a meta-analysis of retrospective cohort studies