Introduction Metabolic dysfunction-associated fatty liver disease (MAFLD), formerly named as non-alcoholic fatty liver disease (NAFLD), is characterized as excessive lipid accumulation within hepatocytes with overweight/obesity, presence of type 2 diabetes mellitus, or evidence of metabolic dysregulation (Eslam et al., 2020)
Indeed, others have shown that depletion of gut microbiota in mice results in elongated intestines, reduced transit speed, elevated permeability, and loss of enteric neurons 27
Jazmin Aguilera: To read more about GLP-1s and addiction, check out Chriss reporting on Globe.com
Thus, pharmacological treatment can have an important impact on gut microbiota, and in turn, gut microbiota can induce pharmacodynamical alterations by transforming drugs or by modifying host metabolism and immune system [244, 245]
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