Guidelines Multiple professional societies, including the ACC, ESC, and ADA, have updated their clinical guideline recommendations to incorporate GLP-1 RAs as a therapy component for patients with T2DM and ASCVD
an early phase 1b study reported that co-administration was feasible and that each components pharmacokinetics were not meaningfully altered by the other, which motivated the phase 3 program [3]
It is necessary to expand extensive chronic clinical trials to evaluate the long-term safety, efficacy, and optimal dosing of polyphenols, examine gene-diet and microbiota-polyphenol interactions to elucidate inter-individual variability, develop innovative delivery systems to improve bioavailability and facilitate clinical translation, and clarify potential drug interactions and safety in vulnerable populations
Regulation of metabolite flux through voltage-gating of VDAC channels
Nusser Z, Lujan R, Laube G, Roberts JD, Molnar E, Somogyi P (1998)