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Tirzepatide activates two receptors: GLP-1 and GIP (glucose-dependent insulinotropic polypeptide)

Because the two target distinct receptors on the same cells, co-exposure in culture is hypothesized to produce complementary actions potentially altering both the amplitude and the duration of GH secretion while mitigating potential receptor desensitization relative to either peptide alone

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(b) Reversal of the loss or apoptosis of hippocampal neurons induced by PTZ toxicity, along with decreased levels of inflammatory markers such as IL-6, TNF- , and IL-1

USA 91 , 883887 (1994)