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In the absence of valine, HDAC6 accumulates in the nucleus and promotes Tet2 (ten-eleven 2) deacetylation, subsequent DNA demethylation, and genomic instability in cancer cells [159]

Best for: weight management metabolic health appetite control Tirzepatide (GLP-1/GIP) Acts on two incretin receptors simultaneously, GLP-1 and GIP, for broader metabolic support

Of the 216 enrolled patients, 102 (47.2%) were not included in the primary analysis because of incomplete questionnaires or loss to follow-up

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