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Because fasted-state absorption allows the peptide to bind NNMT enzymes without interference from competing substrates in the gut

AOD9604 is essentially a modified form of the 176-191 fragment (Tyr-hGH177-191) with a disulfide cross-link that enhances chemical stability

So injecting beyond a certain point may cause your cells to fight off the excess B12 so hard that it might reduce the amount of active cellular B12 - probably not to dangerous levels, but possibly sufficient to trigger some symptoms

Do I need a prescription for a B12 injection

A few research studies have suggested that non-protein nitrogen serves other functions in enzyme regulation, bioactive component storage, gut microbiome development, mucosa development, and immune function but our understanding of the function of non-protein nitrogen is limited