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Moreover, drugs targeting mutant isocitrate dehydrogenase in acute myeloid leukemia (AML) have marked a milestone in precision cancer metabolism therapy, demonstrating the potential effectiveness of metabolic treatment ( Due to its extensive clinical application experience and wide accessibility, traditional Chinese Medicine (TCM) plays a crucial role in cancer treatment in China ( Above all, targeting cancer metabolic abnormalities has been recognized as a promising strategy to remodel the tumor microenvironment and enhance antitumor immune responses

The three FDA-approved medications for AUD remain naltrexone (approved 1994), acamprosate (2004), and disulfiram

Through establishing an interleukin (IL)-1-stimulated chondrocytes, it was found that L-theanine could inhibit the nuclear factor kappa B (NF-B) pathway, thereby reducing the expression of proinflammatory factors, including cyclooxygenase-2 (COX-2), prostaglandin E2, inducible nitric oxide synthase, as well as NO, and protect the degradation of extracellular matrix (30)

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