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The ratio GSH/GSSG is thought to be around 100 for cells that are not under oxidative stress [29] , which aligns closely with the values presented in Table 1

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Further projections from the VTA to the medial prefrontal cortex, an important part of the reward system which also encodes the genes for the GHSR-1a, are described as part of this pathway [99,100,101]

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It allows two independent receptor pathways to be stimulated simultaneously in preclinical models and the resulting potentiation of GH release to be measured