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This safety profile contrasts sharply with full growth hormone, which carries risks of diabetes development, acromegaly (abnormal tissue growth), increased cancer risk, hypertension, and other systemic effects

24 Table 3 Estimated Sensitivity and Specificity of Serum Laboratory Tests for Vitamin B12 Deficiency Pernicious anemia refers to one of the hematologic manifestations of chronic auto-immune gastritis, in which the immune system targets the parietal cells of the stomach or intrinsic factor itself, leading to decreased absorption of vitamin B 12

In general, most people can expect the effects of a B12 injection to last for several weeks to months

Intramuscular injections of B12 are administered during the first stage of the test, an hour after the patient takes an oral dose of radiolabeled vitamin B12

Age-related decrease in B12 absorption