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FK506 attenuated pilocarpine-induced Epilepsy by reducing inflammation in rats

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Funding This work was supported by the National Natural Science Foundation of China (No.81871185), Chongqing Municipal Education Commission (KJZD-K202100407), Chongqing Science & Technology Commission (cstc2021jcyj-msxmX0213), Kuanren Talents Programs of the Second Affiliated Hospital of Chongqing Medical University

Consequently, the accumulated NAPQI binds covalently to the cysteine, methionine, tyrosine, and tryptophan residues of various proteins, forming NAPQI-protein adducts within the cell that disrupt normal physiological protein functions

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