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Biogerontology , 15(2), 183-197

The two hydrogens of the amine and the carbonyl oxygen make up an H 2 O: Amide Dehydration Mechanism by SOCl 2 2 The reaction starts with a nucleophilic attack of the C=O oxygen, which converts into a good leaving group and is then eliminated in the following steps: The last step is irreversible, formed bythe loss of good leaving groups and entropy factors

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References Rowley, J