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GLP-1 receptor activation improves cell function and survival following induction of endoplasmic reticulum stress

Proc Natl Acad Sci USA 85 : 52745278 Di Chiara G, Tanda G

This specific chemical structure acts as a potent reducing agent, allowing it to act like a cellular sponge for highly reactive, unstable molecules known as free radicals or reactive oxygen species (ROS)

However, these adverse effects have been described as mild, with PubMed researchers concluding that berberine is a safe medicinal plant. Furthermore, no serious side effects were reported from berberine use in a study involving 2,569 patients (33)

Eric Topol (42:05): Well, we'll definitely put a link to the Lasker Awards speech that you gave