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Introduction Obesity represents a multifaceted, chronic condition characterized by an accumulation of excessive body fat, known as adiposity, which can impair health and decrease lifespan [ 2 and is subdivided further into class 1 (3034.9 kg/m 2 ), class 2 (3539.9 kg/m 2 ) and class 3 (40 kg/m 2 )

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Diabetes : Nearly 589 million adults worldwide are living with diabetes, projected to reach 853 million by 2050

Cell Metabolism, 17(6), 819837.

In contrast to GLP-1 and oxyntomodulin, however, PYY(3-36) does not seem to have a marked effect on glucose-stimulated insulin secretion when given to human volunteers [40]