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The first cohort included female patients who received a semaglutide or tirzepatide prescription during the study period

Aging is associated with higher expression of metallothionein mRNA, reducing zinc bioavailability, and supplementation can restore zinc levels, enhancing NK cell cytotoxicity [210, 211]

Additionally, there was variation in the quality of included studies as the risk of bias, methodological rigor, and data integrity were not well tracked or standardized across the available articles