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The 1-methylnicotinamide product of NNMT may itself have biological activities (including potential insulin resistance-promoting effects), and reducing its production through NNMT inhibition may contribute to metabolic improvements

(Van Wagoner et al., JAMA, 2017) The practical implications of this data matter more than the headline number

Consistency matters more than perfection A consistent weekly injection of properly stored tirzepatide will always outperform sporadic dosing from a vial with questionable storage history

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