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It only allows a small amount of large molecules like B12 to pass through

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It complements the HIP assay by providing a ranked list of genes (by virtue of their deletion strain sensitivity) that buffer the target pathway, including those that comprise pathway components as well as genes involved in multidrug resistance (e.g., drug transport, detoxification, and metabolism)

The oral capsule format eliminates the reconstitution step required for lyophilized vials