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The peptide backbone becomes chemically unstable above refrigeration temperatures, which can reduce bioavailability and diminish the medication's intended metabolic effects

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Oxidative stress occurs when there is an imbalance of free radicals and antioxidants

GLP-RAs also activate AMPK, and through downstream SIRT1 also inhibit NF-B translocation and thus indirectly suppress proinflammatory gene transcription (80), leading to promotion of autophagy and mitochondrial stability, thereby reducing damage-associated molecular patterns that sustain microglial activation (81)