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Maybe its not the GLP-1 thats doing something, but rather the patients who receive GLP-1 drugs may differ from other patients in ways that affect cancer outcomes, including weight, diabetes control, access to care, screening, other medications, and overall health

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Weight loss was also assessed in the SCALE Sleep Apnea RCT, in which 359 non-diabetic individuals (mean age 48.5 years, mean BMI 39.1 kg/m 2 ), mostly males with untreated obstructive sleep apnea (OSA), were enrolled to investigate the effect of liraglutide on disease severity 20

Thus, any experiment with gene knockout mice needs to consider adaptive mechanisms that can affect signaling mechanisms and the mode of cell death