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Oxymetazoline vs Brimonidine for Management of Persistent Facial Erythema Oxymetazoline is an alpha-1a adrenoceptor agonist that causes topical vasoconstriction to lessen erythema associated with rosacea.6 Brimonidine is also a vasoconstrictor, though, it works through selective alpha-2 adrenergic agonism to exert its vasoconstricting effect.7 Brimonidine has a rapid onset within 30 minutes and begins to wear off at 10 to 12 hours at which point some patients report the return of erythema

For now, the Canadian approval for RYBELSUS applies only to adults with type 2 diabetes who also have cardiovascular disease or are at high risk of heart disease

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vaginalis and in adults with a history of urogenital contact [162]