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When the supply of amino acids is reduced, it affects the renewal of cells, which causes, in particular, the thinning of the dermis

The LMNA gene is composed of 12 exons, and alternative splicing in exon 10 produces two mRNAs that encode for pre-lamin A and lamin C

The overarching cardioprotective effect is achieved through the restoration of mitochondrial integrity and function, as evidenced by the recovery of key components (e.g., SCO1, CCO, and SOD1) and upregulating the biogenesis regulator PGC-1 [51, 204]

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