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Because its research-grade (rather than consumer-approved) and considering its ability to cross the blood brain barrier, the key is: start modestly, track your response, and adjust only when justified

This largely comes from bioavailability studies such as a randomized, controlled trial from 2018, which showed identical doses of ubiquinone and ubiquinol resulting in greater serum CoQ10 concentrations among the ubiquinol group.34 Thats certainly important, but it was a very small study (only ten participants), and it doesnt give us a sense of actual efficacy for any use case

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The cells were incubated at room temperature for 30 minutes in the dark, and the cell cycle was analyzed by flow cytometry (Win Bryte HS cytometer [Bio-Rad], using software Win Bryte, Bio-Rad Laboratories Inc., Hercules, CA, USA)