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A small number of human studies from the 1980s and 1990s reported improvements in sleep architecture and reduced insomnia symptoms, but these trials had very small sample sizes (often under 20 subjects), lacked rigorous controls, and have not been replicated with modern methodology

This is simply the nature of momentum, but there was some interesting discussion surrounding the drawdown that I felt deserved elaboration

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In some embodiments, the otic formulation or composition comprises about 0.01% to about 1% by weight of the poloxamer