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The peptide interacts with the nitric oxide system, which regulates blood flow, inflammation, and cellular signaling

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However, the exact mechanism by which IGF-1 improves insulin signalling has not yet be explained (other than indirect actions through lipid clearance from the bloodstream by inhibiting GH (lipolysis on adipocytes) and FFA uptake by muscles

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Exenatide treatment did not affect bone mineral density despite body weight reduction in patients with type 2 diabetes