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doi: 10.3390/ijms22157963 76 FajgenbaumD
Yoo M-H, Gu X, Xu X-M, Kim J-Y, Carlson BA, Patterson AD et al (2010) Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimers disease
Similar content being viewed by others Introduction Class I glutaredoxins (Grx) are glutathione-dependent thiol:disulfide oxidoreductases that reversibly convert a variety of low or high molecular weight disulfide substrates using the cysteinyl-containing tripeptide glutathione (GSH) as a reducing agent (EC 1.8.4.14) 1,2,3,4,5,6,7,8
Previous studies documented the protective effects of Hsp70 for maintaining lysosomal integrity, showing that it can stabilize lysosomal membrane by binding to lipid bisphosphonates and enhancing the activity of acidic sphingolipase 78,79