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Cancer Immunol Immunother 69(8):1519-1534, 2020
A group at the Walter Reed Army Institute of Research (WRAIR) created prefusion-stabilized S-trimer-ferritin nanoparticles (SpFNs) , which were shown to be stable candidate immunogens that elicited potent nAb titers against SARS-CoV-2 variants and robust protection against challenge in a K18-hACE2 mouse model [128, 129] (Table 3)
Combine with MK677:
Reconstituted peptides left at room temperature degrade rapidly through accelerated hydrolysis, oxidation, and bacterial growth
Most patients who go off the drug cannot successfully maintain their target weight without maintenance
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