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Given that both diet composition and adiposity can each substantially impact the gut microflora in obese mice 24 , we conducted a secondary endpoint study using animals given the same series of diets to test the hypothesis that NNMTi treatment combined with LD, but not LD alone, shifts the cecal microbiome profile of obese animals to be similar to age-matched LD controls that were never given a high-fat diet

Most IV treatments take 30-45 minutes to administer

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insert the needle at 90 (or 45 if very little subcutaneous fat) into subcutaneous tissue [7]

The cellular phenotypes linked to the Werner syndrome demonstrate significant overlap with laminopathies