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OCSCs promote the polarization of macrophages into the tumor-promoting M2 phenotype through the secretion of cytokines rather than direct cell-to-cell contact

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However, the intranasal route of drug delivery still has some unresolved issues, such as the need to overcome cilia and mucosal clearance in the vestibular region, as well as enzymatic degradation after the introduction of nanotherapeutic formulations into the nasal cavity[166]

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Tokede OA, Onabanjo TA, Yansane A, Gaziano JM, Djouss L