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Losing weight already increases the risk of gallstones, and GLP-1s seem to increase it even further

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[1] Tirzepatide acts through two incretin receptors at once , GIP and GLP-1, adding a glucose-dependent insulin-secretion effect that an amylin analog does not have

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5b, S2d)

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As tirzepatide was compared to controls, the hazard ratios for MACE-4 were 0.80 (95% confidence interval [CI], 0.571.11), cardiovascular death was 0.90 (95% CI, 0.501.61), and all-cause death was 0.80 (95% CI, 0.511.25) [2]

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