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In addition, the results of cytotoxicity on human keratinocyte (HaCaT cells) showed lower toxicity potential for the prepared arbutin-loaded polymeric nanoparticles ( The application of N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride as a liposome surface coating material was accompanied by enhanced kojic acid skin permeation and reduced melanin synthesis in comparison to the conventional liposomal kojic acid formulation (Wang et al., 2012a

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