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One could hypothesize that these endoperoxide drugs accumulate and act on targets that lead to the production of reactive oxygen species, which ultimately affect cytosolic GSH levels

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While semaglutide and tirzepatide are currently FDAapproved options within this category, additional peptide therapies such as retatrutide are in advanced clinical trials

HC neutrophils (n = 5) were cultured with 20% HC or SLE serum in the presence or absence of LPX-1 (1 M) for 16 hours before analysis

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