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Inhibitory Effect of Crocin(s) on Lens alpha-Crystallin Glycation and Aggregation, Results in the Decrease of the Risk of Diabetic Cataract
Under homeostatic conditions, the ECs maintain the integrity of blood vessels, modulate blood flow, deliver nutrients to the underlying tissues, regulate fibrinolysis and coagulation, control platelet adherence and patrol the trafficking of leukocytes (Figure 2A) (Figure 2B) ( Figure 2 According to the epidemiological studies, diabetes mellitus is considered as one of the main risk factors for CVD (Figure 1) ( Diseases such as T2DM that induce high levels of vascular injury are accompanied by an elevated number of circulating endothelial cells (CECs) (Figure 2C) ( Macroangiopathies, by inducing atherosclerosis in the coronary, carotid, and peripheral arteries, increase the risk of myocardial infarction (MI), stroke and peripheral artery disease (PAD)
Natural alternatives include vitamin C serums, kojic acid from rice bran, arbutin from bearberry plants, and liquorice extract
However, standard capsules can sometimes cause mild bloating or gas, which might feel uncomfortable for those with sensitive stomachs
