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Future of GLP-1 Medications: In Development: Oral formulations (Rybelsus exists but less effective) Monthly injection versions Triple agonist medications (GIP/GLP-1/glucagon) Combinations with other weight loss mechanisms The GLP-1 class will likely dominate weight loss treatment for the next decade while continuing to improve

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It's not that IM 'doesn't work'

[124] conducted a double-blind, practical trial in which participants were randomly assigned to receive exenatide or placebo to measure changes in carotid plaque volume and composition at 9 and 18 months of treatment, and found no difference in mean change in plaque volume in the exenatide group compared with placebo

The Benefits of Starting a GLP-1 Earlier in Type 2 Diabetes: Key Takeaways Our main message is this: the way we treat type 2 diabetes needs to change